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Biomarker Discovery

Decode disease at the molecular level

Biomarkers are biological indicators, such as genes, proteins, or other measurable biological characteristics, that can be used to detect, diagnose, or monitor various diseases and health conditions.

Better biomarkers are urgently needed to guide molecularly targeted therapy, monitor therapeutic response, and improve diagnosis across a wide spectrum of disease.​ The process of biomarker discovery enables researchers to identify these critical indicators.

Revvity offers comprehensive tools for preparing and analyzing samples across diverse biomarker categories. Our biomarker discovery solutions leverage multiplex and multi-omic approaches, empowering you to uncover the molecular signatures of diseases across a wide range of biological samples.
 

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For research use only. Not for use in diagnostics procedures.

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Solutions for key biomarker types

Explore our comprehensive solutions for key biomarker types, designed to transform your biomarker discovery and unlock new insights into disease mechanisms. For full project services, our Revvity Omics Services team can collaborate with you to create specialized biomarker assays tailored to your unique research requirements.

DNA-RNAbasedBiomarker

DNA and RNA biomarkers

DNA and RNA are powerful biomarkers in research and diagnostics, from gene expression and molecular signatures through treatment prognosis.
 

DNA and RNA are powerful biomarkers in research and diagnostics, from gene expression and molecular signatures through treatment prognosis.
 

Revvity offers comprehensive solutions for DNA and RNA (coding and non-coding) biomarker identification, from sample preparation to large-scale automation. These tools facilitate efficient isolation, amplification, and analysis of nucleic acid biomarkers for precision medicine and drug development - supporting next-generation sequencing applications such as single-cell, targeted, and metagenomics sequencing. Additionally, our solutions support the analysis of ctDNA, cfDNA, miRNA, and cfRNA.

  • Sample homogenizers
  • Nucleic acid isolation
  • Library prep kits
  • Library prep automation
  • DNA, RNA and NGS library analysis
  • Mimix™ reference standards
  • BioLegend Multiomics Analysis Software
  • Single-cell sequencing
SolubleSecretedProteinBiomarkers

Soluble or secreted protein biomarkers

Soluble proteins, such as cytoplasmic proteins and enzymes, and secreted proteins, such as cytokines or antibodies, play important roles in metabolism, signaling, and immune defense.
 

Soluble proteins, such as cytoplasmic proteins and enzymes, and secreted proteins, such as cytokines or antibodies, play important roles in metabolism, signaling, and immune defense.
 

Revvity provides biomarker assay solutions including sample homogenizers, microplate readers, immunoassay kits, and reagents for single and multiplex detection of numerous proteins. Choose from different technology platforms depending on your study question, sensitivity, dynamic range and throughput needs.

Single plex protein detection:
  • Wash and no-wash immunoassays
Multiplex protein detection:

Quantify up to 14 cytokines or analytes with our bead-based multiplex immunoassays on your flow cytometer.

  • BioLegend LEGENDplex™
Instruments:
  • Sample homogenizers
  • Mini ELISA Plate Reader™
  • Microplate readers
Workflow automation and software:
  • Integrated laboratory automation
  • Automated liquid handling workstations
  • LEGENDplex data analysis software suite
  • Signals software
     
SurfaceProteinBiomarker

Cell surface protein biomarkers

Detection of cell surface proteins is crucial to identify cell types and understand their various cellular functions.

Detection of cell surface proteins is crucial to identify cell types and understand their various cellular functions.


Flow cytometry workflows

Flow cytometry is essential for cell surface protein analysis, providing rapid, multi-parameter data at the single-cell level. Enhance your flow cytometry analysis with BioLegend antibodies.

  • BioLegend flow cytometry reagents

Utilize surface proteins to isolate and purify cells of interest for downstream analysis. Our magnetic bead-based cell separation system uses antibodies for either positive or negative selection of cells from heterogenous samples.

  • Mojosort™

A crucial step in flow cytometry is the accurate preparation of reagents. Our liquid handling solutions enhance your productivity and support reliable antibody panel preparation.

  • Flow cytometry cocktail prep automation

Using flow cytometry and our lyophilized antibody arrays, you can screen hundreds of cell surface markers on mouse or human cells and determine your target cell antigen profile.

  • BioLegend LEGENDScreen™

Leverage cloud-based software for real-time visualization of flow cytometry data.

  • CytoScribe™ software
Multiomics

Multiomic analysis integrates various levels of molecular information for deeper biological insights. Our TotalSeq reagents enable simultaneous detection of proteins and RNA or DNA in single-cell sequencing experiments, enhancing multiomic research capabilities.

  • BioLegend multiomics and TotalSeq™ reagents
TissueBasedBiomarker

Tissue biomarkers

Tissue-specific biomarkers that contribute to the organization and heterogeneity of tissues offer deeper insights into disease mechanisms and precision medicine.
 

Tissue-specific biomarkers that contribute to the organization and heterogeneity of tissues offer deeper insights into disease mechanisms and precision medicine.
 

By combining the high-resolution molecular profiling of single-cell sequencing with the spatial context provided by spatial biology techniques, researchers can gain a holistic understanding of tissue organization to fuel biomarker discovery.

Our tissue biomarker discovery solutions support researchers in decoding complex cellular landscapes and advancing spatial biology studies.

Spatial omics
  • TotalSeq™-Bn reagents
  • Morphological markers
Immunofluorescence
  • Antibodies and other reagents for IHC/ICC
Multiplexed/sequential immunofluorescence
  • Antibodies supporting CellScape™
  • Antibodies supporting hyperplexing with COMET™
  • Antibodies supporting IBEX

Featured resources

Application note

Unlocking the potential of small RNA biomarkers with Revvity’s automated workflow

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Publication review

Extracellular vesicles: Discovery tools to pioneer the next wave of biomarkers

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Application note

Utilization of AlphaLISA technology to accurately detect asthma biomarkers in human serum

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Application note

TotalSeq™ and DepleteX technologies for efficient analysis of the cellular transcriptome

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Webinar

Extracellular vesicles in liquid biopsies for neurological disorders

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View all resources View all resources

Featured blogs

What to consider when choosing a homogenizer for your lab
What to consider when choosing a homogenizer for your lab.

Choosing a lab bead mill, rotor stator homogenizer, sonicator from sample characteristics, application needs, equipment features, usage, and maintenance

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How extracellular vesicles are reshaping biomarker discovery.

Explore how extracellular vesicles are transforming biomarker discovery through advanced profiling techniques

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Small RNA biomarkers in cancer: how NGS is revolutionizing miRNA-based research.

Explore how small RNA sequencing and NGS are transforming cancer biomarker discovery. Learn why miRNAs are key to precision oncology and liquid biopsy research.

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What to consider when choosing sonicators for tissue and cell lysis.

Top considerations when choosing a sonicator for your lab. Ultrasonic baths, probe sonicators, homogenizers for cell lysis.

non-invasive Biomarkers
Why are miRNAs promising non-invasive Biomarkers?

Discover how miRNAs serve as promising non-invasive biomarkers in cancer, acting as tumor suppressors or oncogenes by regulating genes involved in tumor growth.

Single-cell RNA sequencing shown to be a robust tool for identifying predictive biomarkers across multiple sites
Single-cell RNA and protein sequencing as a robust tool for multisite biomarker detection.

This blog serves as an introduction to a Nature paper that addresses single-cell RNA sequencing and how it can be used as a robust tool for identifying predictive biomarkers across multiple sites.

maximizing the impact of single-cell sequencing
Maximizing the impact of single-cell sequencing by addressing current bottlenecks.

The human body is formed of a large diversity of cells and cell types, each with unique expression patterns and molecular complexities.

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Exploring circulating extracellular vesicles in liquid biopsies for neurological disorders webinar.

Discover how extracellular vesicles in liquid biopsies offer insights into neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS in this blog.

FAQs

 

  • How do I choose between different biomarker discovery solutions for my specific research needs?

    The optimal biomarker discovery path depends on your specific research question and may involve sequencing applications, immunoassays, flow cytometry, spatial analysis, or a strategic combination to create a comprehensive multi-omics approach. Revvity's expert support teams are available to guide you through our solution portfolio and identify the best fit for your project requirements.

    For those who prefer to outsource their research, our dedicated Revvity Omics Services team can design and customize tailored solutions specifically aligned with your research objectives.

  • Do you offer custom biomarker discovery services?

    Yes, we offer comprehensive custom service solutions including specialized antibodies and assay development through BioLegend, from Revvity. We also provide other custom options for converting ELISAs to no-wash immunoassays. To explore these services, please visit:

    • BioLegend custom services
    • Revvity’s assay development services

    For full project services, our Revvity Omics Services team can collaborate with you to create specialized biomarker assays tailored to your unique research requirements.

  • Do you offer automation solutions to streamline biomarker discovery workflows?

    Yes, Revvity provides comprehensive automation solutions to enhance efficiency and reproducibility in biomarker identification. Our automation portfolio includes liquid handling workstations, integrated lab automation systems, and specialized flow cytometry cocktail prep workstations. Additional solutions include instruments for nucleic acid extraction, sequencing library quantification and sizing LabChip GXII Touch HT Protein Characterization System Discover , and non-contact dispensers for precise sample handling.

  • Do you provide analysis software for biomarker assay data? 

    Yes, Revvity offers comprehensive software solutions to support your biomarker discovery data analysis needs. Our portfolio includes Multiomics Analysis Software for multi-omics data analysis, Signals software suite for integrated data management and analysis, CytoScribe™ software for advanced cytometry data processing, and the LEGENDplex™ software suite specifically designed for flow cytometry analysis of the LEGENDplex assays.

Related solutions

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プレシジョン・メディシン・リサーチ

数え切れないほどの病気、特に癌は、その性質が非常に不均一であるため、これらの病気を効果的に治療したり闘ったりするためには、1つの薬物ですべてをまかなうというアプローチは現実的ではありません。
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Single-cell Sequencing

Single-Cell Sequencing

Single-cell analysis identifies information often overlooked by bulk approaches. We offer solutions for key steps in the single-cell sequencing workflow.
Learn more
ngs workflows

NGSワークフロー

The library preparation workflow is the process of getting DNA or RNA ready for Next Generation Sequencing (NGS).
Learn more
flowtile-512x288

Flow Cytometry

Our flow cytometry hub allows you to browse through our extensive catalog of reagents or explore the founding concepts of flow cytometry experiments.

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Single Cell Analysis

Single-cell Analysis

Transform traditional single-cell sequencing experiments by achieving unparalled protein and genetic analysis with our multiomics solutions.

Learn more
biomarker detection reagents

Biomarker detection reagents

Our biomarker detection reagents and kits are designed to excel in applications that rely on high sensitivity, wide dynamic range, and easy automation.
Learn more | View products
mirna-seq-analysis-thumbnail

miRNA-seq Analysis

There are different species of small non-coding RNAs (sncRNAs) that play critical roles in various regulatory processes such as transcription, post-transcription, and translation.
Learn more
Exosome cfRNA Analysis

Exosome/cfRNA Analysis

Extracellular vesicles are membrane-bound compartments which are being increasingly recognized as important players in cell-to-cell communication.
Learn more
ctdna-workflows-thumbnail

ctDNA Workflows

Analyzing circulating tumor DNA (ctDNA) offers a non-invasive, dynamic window into the body’s physiological state and its use as a biomarker is gaining rapidly.
Learn more
preclinical services

Preclinicalサービス

生産性の向上、データ解析の強化、そして再現性・スケーラビリティ・信頼性の確保を実現する、包括的なソリューションを提供します。
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Revvity omics services

Revvity Omics Services

A global leader in omics testing, Revvity Omics provides a comprehensive array of clinical and pharma services to support research and diagnosis in rare and common diseases.
Learn more
biobank automation

Biobanking Workflows

Facing an ever-increasing demand, biobanks empower labs to increase our understanding of complex diseases by delivering the right resources, to the right researcher, at the right time.
Learn more
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Streamlining NGS: A comprehensive guide from sample prep to QC

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