Extracellular vesicles: Discovery tools to pioneer the next wave of biomarkers

Extracellular vesicles (EVs) represent a fascinating frontier in biomarker discovery. Secreted by virtually all cell types, these vesicles circulate in biological fluids carrying molecular cargo that reflects their parent cells’ composition - offering unique insights into cellular function and disease processes through minimally invasive sampling.

Effective isolation and characterization methods are required to make the most of the valuable information contained within EVs. Traditional approaches are often labor-intensive and demand large sample volumes, but recent advances help address these limitations.

This literature review explores the emerging role of EVs as biomarkers and the technical advances overcoming key barriers to their application in research and diagnostic applications.

Learn about:

• Evolving EV isolation and analysis technologies using minimal sample volumes
• High-throughput miRNA profiling using acoustic trapping combined with NEXTFLEX™ Small RNA-Seq
• Multiplex detection of EV surface proteins using TotalSeq™-A antibody-based immuno-PCR

For research use only. Not for use in diagnostic procedures.