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  • Operetta CLS ハイコンテントアナリシスシステム

Operetta CLS ハイコンテントアナリシスシステム

Operetta CLS™ ハイコンテントアナリシスシステムの導入は、日常的なアッセイや革新的なアプリケーションにおいて、新しい生物学的知見を得ることができます。ユニークな技術を備えたOperetta CLSは、表現型解析のために必要な速度、感度、解像度を備えており、さらに、シンプルながら強力なHarmonyソフトウェアによって、Operetta CLSは微細な表現型の差異も見つけ出すことができます。

本製品は研究用です。診断用にはご使用いただけません。
Part #: HH16000020
Imaging Modality:
明視野, Confocal, Digital phase contrast, 蛍光
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Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
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Operetta CLS ハイコンテントアナリシスシステム
Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Video Play Button
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Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Operetta CLS High-Content Analysis System
Operetta CLS ハイコンテントアナリシスシステム
Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Operetta CLS High-Content Analysis System
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
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明視野, Confocal, Digital phase contrast, 蛍光
Imaging Modality: 明視野, Confocal, Digital phase contrast, 蛍光
Part #: HH16000020
Request information

Product information

  • Overview
  • Additional product information
  • Specifications
  • Image gallery
  • Video gallery

Overview

Operetta CLSシステムは、Operettaプラットフォームから信頼を得ているパワフルで直感的なデータ解析と、スピードと感度を兼ね備えています。新しいOperetta CLSは、ハイコンテントアナリシスに必要なすべてを備えています。さらに、Operetta CLSシステムは包括的なHCSワークフローの一部です。HCSシステムやマイクロプレートをはじめ、オートメーションやインフォマティクスまで、あらゆるソリューションを提供します。すべてを、信頼できる一社からご提供します。ユーザーフレンドリーなHarmony™ソフトウェアは、研究者自身で解析を行うことを可能し、このHarmony解析ソフトウェアとハイコンテントイメージングとの組み合わせにより、日常的な解析から応用的な解析までのすべてを実行できます。

Applications

汎用的なアッセイからより複雑なアプリケーションまで、Operetta CLSハイコンテントアナリシスシステムは多様な励起波長、高感度な光学系、そして高精度なソフトウェア機能の適切な組み合わせにより、あらゆるアプリケーションから、さまざまな生物学的発見を得ることを可能にします。

固定細胞アッセイ

  • 最大8波長の高出力励起源とユーザーがアクセス可能なエミッションフィルターにより、様々な蛍光色素や、蛍光タンパクに対応可能です。さらに、アプリケーションにより広視野蛍光イメージングまたは、スピニングディスク共焦点イメージングを選択できます。

ライブセルアッセイ

  • スピニングディスク共焦点光学系と同期された高出力LED光源により、安定した励起が得られ、光毒性と褪色を最小限にしたライブセルアッセイを実現します。明視野またはデジタルフェイズコントラストイメージングモードを選択できます。

複雑な細胞モデル

  • ラージフォーマットsCMOSカメラと水浸対物レンズの組み合わせは、高感度と高解像度を提供し、高度な画像解析ソフトウェアは、複雑な細胞モデルがもたらすイメージングと解析の課題を解決します。

アドバンスドアッセイ

  • FRETは、タンパク質間相互作用や構造変化を調べるための強力なツールです。Operetta CLSシステムの高感度イメージングと、レシオメトリックイメージング専用の解析ツールにより、確実な結果が得られます。

表現型フィンガープリンティング

  • Operetta CLSの高解像度イメージングと高度な解析ソフトウェアは、細胞表現型の僅かな差異を解析・数値化し、表現型フィンガープリント作成を実現します。

HCS ワークフローをトータルでサポート

  • ハイコンテントスクリーニング用に開発されたPhenoPlate™マイクロプレートで優れた結果を得ることができます。
  • cell paintingキットを含むPhenoVue™ cellular imaging 試薬との併用
  • Operetta CLSシステムの自動化は、スループットと生産性を向上させます。または、Revvityの提供する自動化された細胞解析ワークフローや創薬ワークフローの活用は、さらなる効率化を実現します。
  • Signals Image Artist™画像解析・管理プラットフォームに結果をエクスポートすることで、Operetta CLSおよび他のHCSシステムからのすべての細胞画像データにアクセス、再解析、保存、共有することができます。
  • Signals VitroVivoの強力な多変量解析と教師なしの機械学習機能は、、明確な細胞フィンガープリントを定義するパラメータを特定することができます。

Additional product information

Operetta CLS is a high throughput microplate imager for high-content analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images. The combination of high power LED excitation with fast, precise mechanics and one large format sCMOS camera enables fast imaging. Controlled by Harmony software it offers a seamless workflow, for reliable discrimination of phenotypes even in complex cellular models

Features at a glance
 

Intelligent image acquisition

Intelligent image acquisition

Target more accurately your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.

Machine learning

Machine learning

Easily create algorithms without being an image analysis expert using our PhenoLOGIC proprietary machine-learning technology.

Easily Quantify Cellular Phenotypes in Complex 3D Models

Easily quantify cellular phenotypes in complex 3D models

Explore your cell models by visualizing them in a 3D- and an XYZ-viewer and quantify volumetric and other 3D related phenotypic readouts.

Powerfully simple analysis capabilities

Powerfully simple analysis capabilities

Harmony® high-content imaging and analysis software - is the easy-to-learn, easy-to-use software that can make you more productive - faster.

High efficiency excitation design

High efficiency excitation design

Direct coupling limits the light loss that is typical of light guides or fibers.

Fast Frame Rate Imaging

Fast Frame Rate Imaging

Capture rapid cellular changes with an imaging frame rate up to 105 fps.

Automated water-immersion objectives

Automated water-immersion objectives

From the company with more than 20 years of experience - giving faster exposure times, increased resolution and reduced photodamage.

Confocal spinning-disk technology

Confocal spinning-disk technology

Provides a gentle imaging process (especially for live-cell experiments) with efficient background rejection.

 

 

operetta cls banner

 

Customer testimonials

A solution configured to suit every need

Whatever your application, there’s an Operetta CLS system configured to meet your requirements. And it’s modular, so it can change with your research demands.

Operetta CLS configurations

Quattro

Operetta® CLS™ Quattro

Ideal for common applications that need sensitivity and resolution, with the capacity to grow if the need arises.

FLEX

Operetta® CLS™ FLEX

Offers flexibility in excitation and imaging modes for many challenging applications – and it can be upgraded to even higher performance.

LIVE

Operetta® CLS™ LIVE

Ideal for gentle yet highly sensitive live-cell imaging.

    Quattro FLEX LIVE
System Options Camera sCMOS sCMOS sCMOS
Number of LEDs 4 8 8
Confocal Disk º • •
Environmental Control º º •
Water Immersion º º •
Transmitted Light • • •
Robotics/Automation Compatible • • •
Imaging Modes Fluorescence Widefield Imaging • • •
Confocal Flourescence º • •
Brightfield and Digital Phase Contrast • • •
Ratiometric FRET • • •
3D Imaging º • •
Live-Cell Imaging º º •

• Includedº Optional

Specifications

Dimensions 66.0 cm (W) x 98.0 cm (D) x 45.0 cm (H)
Automation Compatible
Yes
Brand
Operetta CLS
Imaging Modality
明視野
Confocal
Digital phase contrast
蛍光
Unit Size
1 unit

Image gallery

Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Operetta CLS ハイコンテントアナリシスシステム
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Operetta CLS ハイコンテントアナリシスシステム
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.
Primary rat neurons imaged on the Operetta CLS high-content analysis system.
"Human ovarian granulosa tumor cell line imaged on the Operetta CLS high-content analysis system. "
iPSC-derived human cortical neurons imaged on the Operetta CLS high-content analysis system.
Macrophages imaged on the Operetta CLS high-content analysis system.
Drosophila abdomen imaged on the Operetta CLS high-content analysis system.
iPSC-derived motor neurons imaged on the Operetta CLS high-content analysis system.
HPAF-II cells imaged on the Operetta CLS  high-content analysis system.
HeLa cells imaged on the Operetta CLS high-content analysis system.

Video gallery

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Operetta CLS ハイコンテントアナリシスシステム
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Operetta CLS ハイコンテントアナリシスシステム
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Citations

Resources

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1-6 of 68 Resources
Application Note Icon
Application Note
3D Analysis of Cell Invasion using Operetta

Here, we present a method for analyzing cell invasion into a 3D extracellular matrix using the Operetta® high-content analysis...

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Brochure
3D cell culture workflow solutions

More than ever, researchers are turning to 3D cell cultures, microtissues and organoids to bridge the gap between 2D cell cultures...

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Technical Note Icon
Technical Note
3D volumetric analysis of luminal spaces inside cysts or organoids

High-content assays using 3D objects such as cysts or organoids can be challenging from the perspectives of both image acquisition...

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Technical Note Icon
Technical Note
3D volumetric and zonal analysis of solid spheroids

Multicellular 3D “oids” (tumoroids, spheroids, organoids) have the potential to better predict the effects of drug candidates...

Learn more
Application Note Icon
Application Note
A multiparametric live-cell cytotoxicity analysis using the Operetta High-content Analysis System

The detection of compound cytotoxicity is an essential part of drug discovery. In this work we describe a rapid and flexible image...

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Case Study Icon
Case Study
A workflow to characterize and benchmark human induced pluripotent stem cells

The UK-based Human Induced Pluripotent Stem Cell Initiative (HipSci) aims to offer the scientific community access to a vast panel...

Learn more
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