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HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
Generic Vial HTRF
| Feature | Specification |
|---|---|
| Application | セカンドメッセンジャー検出 |
Product variants
Unit Size: 40 assay points
Part #:
62AMXADA
Unit Size: 500 assay points
Part #:
62AMXADC
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption, and disposal requirements under European REACH regulations (EC 1907/2006).
HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
Generic Vial HTRF
HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
Product information
Overview
PDEs are represented by a large super-family of enzymes whose role is to hydrolyze cAMP into AMP, and cGMP into GMP. It should be emphasized that while not all PDEs lead to the specific hydrolysis of cAMP, the non-selective PDE inhibitor IBMX is often the preferred chemical used in most cAMP accumulation assays.
The use of a Pan-PDE inhibitor ensures that the hydrolysis effect of most PDEs will be inhibited, which in turn guarantees high levels of cAMP accumulation in the cell.
Specifications
| Application |
Second Messenger Detection
|
|---|---|
| Brand |
HTRF
|
| Detection Modality |
HTRF
|
| Product Group |
Buffer
|
| Shipping Conditions |
Shipped Ambient
|
| Target Class |
GPCR
|
| Technology |
TR-FRET
|
| Therapeutic Area |
Cardiovascular
Infectious Diseases
Metabolism/Diabetes
NASH/Fibrosis
Neuroscience
Oncology & Inflammation
Rare Diseases
|
| Unit Size |
500 assay points
|
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HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
HTRF IBMX Phosphodiesterase Inhibitor, 500 µL
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Technical Note
A simple method for preparing GPCR membrane model extracts from stable cell lines for use with the HTRF GTP Gi binding assay
G-protein coupled receptors (GPCRs) are crucial transmembrane proteins involved in cellular signal transduction.
This technical...
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