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N-succinimidyl-3-(4-hydroxy-3-[¹²⁵I]iodophenyl)propionate, Bolton-Hunter Reagent, 250 µCi

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.

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Feature	Specification
Fresh Lot Days	Fresh upon request
Label Position	Nominally Labeled
Molecular Weight	387.2

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Product variants

Unit Size: 250 µCi

Part #:

NEX120250UC

Unit Size: 1 mCi

Part #:

NEX120001MC

Unit Size: 2 mCi

Part #:

NEX120002MC

For research use only. Not for use in diagnostic procedures.

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Product information

Overview

Iodination of proteins is a common method of adding a tracer with high specific activity to your protein of interest. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative methods. Bolton-Hunter reagent can be used to label peptides and proteins containing lysine residues. Available in 250 µCi size.

Specifications

Physical specifications

Molecular Weight	387.2
Specific Activity	2200 Ci/mmol (81.4 TBq/mmol)
CAS Number	34071-95-9

Other specifications

Application	Drug Discovery & Development
Brand	NEN Radiochemicals
Buffer/Solvent	Anhydrous 2-methyltetrahydrofuran with 250 ppm BHT (butylated hydroxytoluene) stabilizer
Detection Modality	Radiometric
Fresh Lot Days	Fresh upon request
Label Position	Nominally Labeled
Molecular Formula	C13H11I2NO5
Packaging	NENSure vial
Radioisotope	¹²⁵I
Shipping Information	Shipped Ambient
Shipping Conditions	Shipped Ambient
Special Ordering Information	This is a radioactive product - shipping address must have a license to receive radioactive materials.
Storage Conditions	Ambient or lower
Unit Size	250 µCi