Pre-clinical animal models in research: overview of general utility and proof-of-concept study in forensic toxicology applications

Technology or method development is an important, even sometimes overlooked, area of research as labs and scientists look for assays, techniques, modes of standardization that lessens the time-to-results or that helps increase analytical reproducibility. In this webinar, our two speakers discuss the implementation of an alternative and quick method of extracting compounds such as opioids from bone samples, leveraging pre-clinical animal models and benchtop solutions that accelerates sample prep.

• Dr. Cohen will describe the general utility of pre-clinical animal models in his experience for accelerating research and drug discovery & development (DDD) funnels, as he reviews the applicability and importance of pre-clinical animal models in various studies in basic/translational research, disease modeling, or ADMET studies.
• Dr. Alves shares her proof-of-concept study in forensic toxicology work studying opioid metabolite detection in rabbits, analyzing these chemical compounds in bones via mass spec to show the capacity of bone to be valuable chemical reservoir for fentanyl in cold cases. She highlights her work on establishing an alternative, fast bone processing workflow leveraging a bead mill homogenizer that significantly lessens analyte prep.

For research use only. Not for use in diagnostic procedures.