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  • When a breakthrough begins with a question: how a customer conversation sparked a new way forward.
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Story

Disease Research

When a breakthrough begins with a question: how a customer conversation sparked a new way forward.

Sometimes innovation starts not in a lab, but in a moment of frustration, when someone doing important work says, "There has to be a better way."

That's what happened when Dimitri Sideris, a scientist at AstraZeneca, reached out to our team earlier this year. His challenge wasn't unusual, he was running critical tests to understand how potential antibody therapies behave inside cells, but the tools he had were slow, restrictive, and often unclear.

For a company developing life-changing medicines, especially oncology therapies, details matter. These tests help determine how therapeutic antibodies move into cells and whether they're behaving as intended, key information for ensuring the safety and certainty required in quality control before a drug reaches an individual. Dimitri needed clearer, faster answers. And he needed an ally who would help him find them. That's where the story truly began.

A challenge shared becomes a solution found

Instead of pointing him back to the manual for the competitor assay he was using, our teams took a different approach. We connected with Dimitri to understand what wasn't working, and more importantly, what would change his experience.

From there, a cross-functional team quickly formed: R&D, Product Management, Field Application Scientists, and Commercial teams working together as one. What Dimitri needed aligned with something our R&D teams had quietly been building, a new reagent called pHSense™, designed to reveal what happens inside a cell more quickly and clearly than existing approaches.

Before launching, pHSense existed only as an exciting innovation in development, but Dimitri's challenge helped accelerate its real-world debut. Our team presented the technology and its benefits directly to him, guiding him through how it worked and how it could streamline his workflow. Dimitri agreed to test it, and a coordinated team moved quickly to make it happen, shipping pre-launch reagents, organizing on-site support, aligning protocols, and designing the demonstration together. It was collaboration in its purest form.

A clearer picture changes everything

During the lab demo, pHSense gave Dimitri faster readouts, clearer signals, and a far simpler workflow, benefits he immediately recognized. What previously took nearly a full day could now be seen within minutes. Instead of struggling to interpret weak or noisy data, he could trust what he was seeing.

The effect on his work was immediate. The new clarity meant he could move projects forward faster. The consistency reduced uncertainty. And the streamlined process made his team's day-to-day work easier. It wasn't just a better reagent; it changed what his QC workflow could look like.

He praised the ease of use, the quality of the data, and the level of support he received, from the responsiveness to the hands-on expertise our teams shared throughout the process.

A new chapter in collaboration-driven innovation

This story isn't just about a reagent. It's about what happens when a customer's challenge becomes everyone's challenge, and when multiple Revvity teams unite to help solve it.

It shows what's possible when we listen deeply, collaborate broadly, and bring science and service together. pHSense didn't just work, it worked because we worked together: R&D, FAS, Product Management, Technical Support, Commercial teams, and a customer willing to co-create the future.

That's the gap we bridge every day. That's Challenge Accepted.


For Research Use Only. Not for use in diagnostic procedures.

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Additional resources

Category

pHSense Reagents

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Brochure

pHSense reagents product list

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Technical note

pHSense Eu probes for time-resolved fluorescence-based monitoring of antibody and ADC internalization

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