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PhenoVue anti-53BP1 - Rat IgG2a Antibody, 100x
PhenoVue anti-53BP1 - Rat IgG2a Antibody, 100x
HeLa cells treated with etoposide followed by staining with the PhenoVue DNA damage response staining kit. γH2AX (phospho S139 H2AX) is shown in green and 53BP1 in red.
Product variant
Quantity: 1 x 100 µL
Part #:
PART53BP111
For research use only. Not for use in diagnostic procedures.
PhenoVue anti-53BP1 - Rat IgG2a Antibody, 100x
HeLa cells treated with etoposide followed by staining with the PhenoVue DNA damage response staining kit. γH2AX (phospho S139 H2AX) is shown in green and 53BP1 in red.
PhenoVue anti-53BP1 - Rat IgG2a Antibody, 100x
Product information
Overview
DNA damage ranges from single-strand breaks (SSBs) to double-strand breaks (DSBs) and complex base modifications. DSBs are the most harmful, leading to genomic instability or cell death if unrepaired. Cells activate the DNA damage response (DDR) to detect and repair damage which is crucial for studying genome stability, assessing cytotoxic agents, and developing anticancer drugs. DSBs trigger the relocalization of key DDR proteins (MRE11/NBS1/RAD50, MDC1, 53BP1, BRCA1) to nuclear foci, where they interact with γ-H2AX. 53BP1 promotes canonical non-homologous end joining (C-NHEJ) over homologous recombination and alternative NHEJ.
The PhenoVue anti-53BP1 – rat IgG2a antibody, part of the PhenoVue DNA Damage Response Staining Kit (PDDR11), supports imaging and high-content analysis applications.
Specifications
| Form |
Solution
|
|---|
| Application |
High Content Imaging
Microscopy
|
|---|---|
| Assay Points |
1 x 384-well microplate
|
| Brand |
PhenoVue™
|
| Host Species |
Rat
|
| Product Group |
Antibody
|
| Quantity |
1 x 100 µL
|
| Sample Type |
Fixed samples only
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Storage Conditions |
-16 °C or below, protected from light
|
| Target Species |
Human
Mouse (predicted)
|
| Type |
Individual reagent
|
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