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AequoZen Human Melanin Conentrating Hormone (MCH2) Frozen Cells
AequoZen Human Melanin Conentrating Hormone (MCH2) Frozen Cells
GPCR Receptor Cells and Membranes
Growth arrested AequoZen™ cell line expressing aequorin and Melanin Conentrating Hormone (MCH2) Receptor, human recombinant, in CHO-K1 host cells. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
| Feature | Specification |
|---|---|
| Application | 創薬・開発 |
| フォーマット | 増殖停止細胞 |
| G-Alpha Coupling Protein | Gα16 |
| G-Alpha Natural Receptor | Gq/G11 |
| Validation | カルシウム発光 |
Growth arrested AequoZen™ cell line expressing aequorin and Melanin Conentrating Hormone (MCH2) Receptor, human recombinant, in CHO-K1 host cells. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light. No cell culture is required prior to testing, for these frozen cells.
Product variant
Unit Size: 1 x 1 mL vial, 10 million cells
Part #:
ES-371-AF
For research use only. Not for use in diagnostic procedures. This product contains living cells.
AequoZen Human Melanin Conentrating Hormone (MCH2) Frozen Cells
GPCR Receptor Cells and Membranes
AequoZen Human Melanin Conentrating Hormone (MCH2) Frozen Cells
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Product information
Overview
Frozen Cells validated for calcium testing: Melanin Concentrating Hormone (MCH2) receptor, human recombinant, in CHO-K1 host cell. We provide one vial of frozen cells (10 million cells/vial). You are authorized to utilize these frozen cell preparations one time only. Any attempt to transfer, re-use, or propagate these cells is expressly unauthorized and a violation of the product terms and conditions of sale.
Features:
- Pre-validated batches of ready-to-use cells for calcium testing
- Optimized to alleviate biological variability
- Step-by-Step protocols for culture-free functional testing on our validated cells
- Affordable access to small aliquots of cells (minimum size: 10 million cells/vial)
- Ready-to-use cells for Profiling, Pharmacology or Screening applications
- Up-scaling and customized developments
The AequoScreen technology is a generic GPCR technology which can be used with Gs, Gi and Gq coupled GPCRs and calcium coupled ion channels. Following receptor stimulation, increases in intracellular calcium enable measurement of the resulting flash luminescence signal.
The frozen cells approach to functional testing consists in the dissociation of cell culture from testing. That means that we will culture the cells and freeze them with an optimized protocol to stop all replication. These cells are then stored in liquid nitrogen or simply in a -80°C freezer, thawed and used directly in a functional, cellular GPCR test with previously validated performance.
Specifications
| Application |
Drug Discovery & Development
|
|---|---|
| Brand |
AequoZen
|
| Format |
Growth-arrested cells
|
| G-Alpha Coupling Protein |
Gα16
|
| G-Alpha Natural Receptor |
Gq/G11
|
| Host Cell Line |
CHO-K1
|
| Host Species |
Human
|
| Receptor |
Melanin-Concentrating Hormone
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Special Ordering Information |
This product contains living cells.
|
| Storage Conditions |
Store in liquid nitrogen (vapor phase) immediately upon receipt, or maximum 15 days at -80°C. AequoZen™ is designed for single use only. Do not refreeze.
|
| Target Class |
GPCR
|
| Therapeutic Area |
Metabolic
|
| Unit Size |
1 x 1 mL vial, 10 million cells
|
| Validation |
Calcium Luminescence
|
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