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IVISense Transferrin Receptor 750 Fluorescent Probe (Transferrin-Vivo)

Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism.

Revvitys IVISense™ Transferrin Receptor 750 fluorescent probe (Transferrin-Vivo™) is a NIR-labeled in vivo imaging probe that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. IVISense Transferrin Receptor 750 fluorescent agent also detects normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.

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Feature	Specification
Unit Size	1 vial (10 doses)
Specificity	Transferrin receptor

Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism.

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Product variant

Wave Length: 750 nm

Part #:

NEV10091

For research use only. Not for use in diagnostic procedures.

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Product information

Overview

IVISense Transferrin Receptor 750 is a targeted fluorescent imaging probe, where recombinant transferrin is conjugated to an IVISense fluorescent dye, designed to bind to transferrin receptors (TfRs) expressed in cancer cells. Because of rapid cell division and stringent demand for iron (for heme synthesis), many cancer cell types overexpress TfRs. It has been used as a targeting agent for cancer cells. In addition, TfR accumulates in locals of inflammation due to the leakage of plasma proteins and to the expression of TfR receptors by inflammatory cells. During inflammation monocytes leave the blood and differentiate into macrophages at the extravascular tissues, macrophages express surface Tf receptors.

Specifications

Other specifications

Brand	IVISense
Fluorescent Agent Type	Targeted
Imaging Modality	Fluorescence
Shipping Conditions	Shipped in Blue Ice
Specificity	Transferrin receptor
Storage Conditions	-30 to -16 °C
Therapeutic Area	Oncology
Unit Size	1 vial (10 doses)
Wave Length	750 nm