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  • IVISense Fluorescent Probes
  • IVISense MMP 645 FAST Fluorescent Probe (MMPSense)

IVISense MMP 645 FAST Fluorescent Probe (MMPSense)

IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense MMP 645 FAST Fluorescent Probe (MMPSense)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes

Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.

Revvity’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.

View product information
Feature Specification
Unit Size 1 vial (10 doses)
Specificity Matrix Metalloprotease

Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.

Revvity’s IVISense™ MMP NIR activatable fluorescence probes (MMPSense®) are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.

View product information
Product variants
Wave Length: 645 nm
Part #:
NEV10100
Wave Length: 680 nm
Part #:
NEV10126
Wave Length: 750 nm
Part #:
NEV10168
For research use only. Not for use in diagnostic procedures.
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IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense MMP 645 FAST Fluorescent Probe (MMPSense)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes - optimized and validated on Revvity's IVIS® optical imaging platform
IVISense MMP 645 FAST Fluorescent Probe (MMPSense)
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
IVISense™ fluorescent imaging probes
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Product information

  • Overview
  • Specifications

Overview

IVISense MMP 645 FAST is excited by 649 nm excitation light, and emits at 666 nm. MMP 645 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that allows for an earlier optimal imaging window of 6-24 hours after injection, facilitating detection of early MMP activity changes, for example in acute models of inflammation or stroke. Including IVISense MMP 645 FAST in careful experimental design allows for multiplexing with other channels and/or imaging times, and so can be paired with other probes to achieve maximum efficiency and flexibility in imaging.

Specifications

Brand
IVISense
Fluorescent Agent Type
Enzyme activated
Imaging Modality
Fluorescence
Shipping Conditions
Shipped in Blue Ice
Specificity
Matrix Metalloprotease
Storage Conditions
+2 to +8 °C
Therapeutic Area
Arthritis
Atherosclerosis
Cardiovascular
Inflammation
Oncology
Pulmonary
Vascular
Unit Size
1 vial (10 doses)
Wave Length
645 nm

Resources

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1-6 of 10 Resources
Flyer Icon
Flyer
Advancing inflammation, arthritis and oncology disease research with IVISense MMP probes
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Flyer Icon
Flyer
Best practices for designing an effective in vivo fluorescence imaging study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into...

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Application Brief Icon
Application Brief
Characterization of NIR fluorophores for their potential in non-specific tissue accumulation
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eBook Icon
eBook
In vivo imaging solutions

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and...

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Guide Icon
Guide
IVISense fluorescent probe selector guide for oncology research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and...

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Application Note Icon
Application Note
Multiplex 2D imaging of NIR molecular imaging agents on the IVIS SpectrumCT platform

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing...

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