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AequoZen Human Melatonin MT1 Cell Line, CHO-K1 Cells
AequoZen Human Melatonin MT1 Cell Line, CHO-K1 Cells
GPCR Receptor Cells and Membranes
AequoZen™ Melatonin MT1 Cells are frozen, ready-to-use cells co-expressing aequorin and the human recombinant Melatonin MT1 receptor, in CHO-K1 host cells. The addition of aequorin provides a way to measure changes in intracellular calcium levels. This specialized cell line is specifically designed and manufactured for use in drug discovery and development, particularly for high-throughput screening assays.
| Feature | Specification |
|---|---|
| Application | 創薬・開発 |
| G-Alpha Coupling Protein | Gα16 |
| G-Alpha Natural Receptor | Gi/Go |
| Validation | カルシウム発光 |
AequoZen™ Melatonin MT1 Cells are frozen, ready-to-use cells co-expressing aequorin and the human recombinant Melatonin MT1 receptor, in CHO-K1 host cells. The addition of aequorin provides a way to measure changes in intracellular calcium levels. This specialized cell line is specifically designed and manufactured for use in drug discovery and development, particularly for high-throughput screening assays.
Product variant
Unit Size: 10 million cells
Part #:
ES-620-AF
For research use only. Not for use in diagnostic procedures. This product contains living cells.
AequoZen Human Melatonin MT1 Cell Line, CHO-K1 Cells
GPCR Receptor Cells and Membranes
AequoZen Human Melatonin MT1 Cell Line, CHO-K1 Cells
Product information
Overview
Revvity's AequoScreen® double transfected cell lines are provided in two vials of frozen cells, each containing ∽2.5 x 106 cells. Detailed product information as well as recommended cell culture conditions and validation assay date are available each cell line.
AequoScreen technology is a generic GPCR technology that can be used with Gs, Gi, and Gq-coupled GPCRs and calcium coupled ion channels. Following receptor stimulation, increases in intracellular calcium enable measurement of resulting flash luminescence signal.
Features:
- Fully automatable and miniaturizable to 1536
- Enables reduction in reagents and consumable costs
- High signal to background ratio enabling detection of agonists, antagonists and allosteric modulators
- Robust assay (Z′, CV values, solvent resistance)
- Reduces number of false positives from autofluorescent compounds in screening libraries
- Option to work with cells in suspension to increase throughput
- Amenable use with calcium coupled ion channels and tyrosine kinase receptors
Revvity's AequoScreen cell lines require accepted cell line Terms and Conditions prior to order processing. Additional agreement needed commercial use. Contact us using Request More Information button above additional information regarding required documentation.
Specifications
| Application |
Drug Discovery & Development
|
|---|---|
| Brand |
AequoZen
|
| G-Alpha Coupling Protein |
Gα16
|
| G-Alpha Natural Receptor |
Gi/Go
|
| Host Cell Line |
CHO-K1
|
| Host Species |
Human
|
| One Unit Contains |
1 M cells/vial
|
| Receptor |
Melatonin
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Target Class |
GPCR
|
| Unit Size |
10 million cells
|
| Validation |
Calcium Luminescence
|
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