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HTRF Human and Mouse Total NPM1, Control Lysate
HTRF Human and Mouse Total NPM1, Control Lysate
Generic Photo vial control lysate (option 3)
| Feature | Specification |
|---|---|
| Application | Cell Signaling |
Product variant
Unit Size: 1 vial
Part #:
64NPMTTDA
For research use only. Not for use in diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption, and disposal requirements under European REACH regulations (EC 1907/2006).
HTRF Human and Mouse Total NPM1, Control Lysate
Generic Photo vial control lysate (option 3)
HTRF Human and Mouse Total NPM1, Control Lysate
Product information
Overview
NPM1 (Nucleophosmin 1) is a molecular chaperone involved in cell cycle regulation, ribosome biogenesis, cell proliferation, DNA damage repair, and apoptosis. Its phosphorylation on Thr199 by the CDK2/Cyclin E complex regulates mitosis, centrosome duplication, pre-mRNA processing, and G2/M cell cycle arrest through its interaction with p53/MDM2.
NPM1 functions both as an oncogene and a tumor suppressor. It is frequently overexpressed, altered, and rearranged, or sporadically deleted, in human cancers. NPM1 is also the most frequently mutated gene (NPM1c) in acute myeloid leukemia (AML).
Specifications
| Application |
Cell Signaling
|
|---|---|
| Automation Compatible |
Yes
|
| Brand |
HTRF
|
| Detection Modality |
HTRF
|
| Molecular Modification |
Total
|
| Product Group |
Control Lysate
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Target |
NPM1
|
| Target Class |
Phosphoproteins
|
| Target Species |
Human
Mouse
|
| Technology |
TR-FRET
|
| Therapeutic Area |
Oncology
|
| Unit Size |
1 vial
|
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