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DepleteX RNA Depletion (Globin)
DepleteX RNA Depletion (Globin)
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This product has been discontinued
The DepleteX® Globin Depletion Kit selectively removes highly expressed globin transcripts (HBA1, HBA2, HBB, & HBD) in vitro before sequencing. This process redirects sequencing resources toward unique biologically relevant transcripts, maximizing UMI and gene sensitivity.
| Feature | Specification |
|---|---|
| Automation Compatible | No |
| Product Group | リボデプレーション |
The DepleteX® Globin Depletion Kit selectively removes highly expressed globin transcripts (HBA1, HBA2, HBB, & HBD) in vitro before sequencing. This process redirects sequencing resources toward unique biologically relevant transcripts, maximizing UMI and gene sensitivity.
Product variant
Discontinued
Unit Size: 24 rxns
Part #:
NOVA-512870
For research use only. Not for use in therapeutic or diagnostic procedures.
DepleteX RNA Depletion (Globin)
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Product information
Overview
Enhance RNA-Seq quality by eliminating globin fragments.
Apart from ribodepletion, RNA samples often contain a limited number of well-characterized, highly expressed transcripts. However, resequencing these transcripts contributes minimally to biologically relevant information. The dominance of highly expressed transcripts hinders coverage for low-expressing counterparts, resulting in reduced sensitivity for detecting disease-related low-expressing genes, rare variants, and unique fusion events.
Globin mRNA dominates the mRNA content of red blood cells and whole blood. Three globlin genes (HBA1, HBA2 and HBB) constitute ≥30% of total mRNA from blood.
Key highlights:
- Unbiased removal of human globin from RNA-seq libraries
- Achieve >99% depletion of contaminating globin
- Rapid one-hour depletion incubation
Specifications
| Automation Compatible |
No
|
|---|---|
| Product Group |
Ribodepletion
|
| Shipping Conditions |
Shipped in Dry Ice
|
| Unit Size |
24 rxns
|
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