Streamlining multi-assay genomics with automated high molecular weight DNA isolation

Your lab is caught between two competing realities. On one side, there's growing demand for comprehensive genetic testing that can detect everything from single nucleotide variants to complex structural changes, repeat expansions, and methylation patterns. On the other, you're working with limited resources — precious sample volumes, constrained turnaround times, and the need for specialized expertise across multiple assay types.

Traditional multi-assay approaches force scientists into an impossible balancing act. It is needed to separate samples for sequencing and methylation analysis. Workflow coordination becomes increasingly complex as scientists manage different protocols, reagents, and timelines. This is especially challenging in pediatric or clinical settings where sample volumes are often severely limited, and sometimes only a single blood draw is possible.

What if one workflow could do it all?

A team at Children's Mercy Hospital developed a unified DNA isolation strategy that supports everything from traditional short-read sequencing to cutting-edge long-read technologies, all from a single sample preparation workflow.

They were searching for a single DNA isolation method that supports all downstream assays, both current and future. This isn't just about convenience — it's about maximizing the testing potential of every precious sample while building a foundation that adapts as genomic technologies continue to evolve.

Their automated workflow delivers 40 µg of DNA per mL of blood with fragment sizes typically exceeding 60,000 base pairs. The 2.5-hour protocol processes up to 48 samples per day with minimal hands-on time. Most importantly, early long-read sequencing results show resolution rates exceeding 50% in initial cohorts — a significant improvement over traditional approaches.

Download this exclusive white paper to discover more details and  and real-world insights with automated high molecular weight DNA isolation.

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For research use only. Not for use in diagnostic procedures.