JP
Revvity Sites Globally
Select your location.
*e-commerce not available for this region.
Case Study
A novel mouse model using optical imaging to detect on-target, off-tumor CAR-T cell toxicity
CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.
Read this case study where researchers from University of Pennsylvania created a mouse model that expresses tumor associated antigens in normal tissue to study off-tumor CAR-T cell toxicity. These studies used optical imaging on the IVIS® platform to longitudinally monitor off-tumor antigen expression, tumor progression, and CAR-T cell trafficking in live animals.
For research use only. Not for use in diagnostic procedures.
To view the full content please answer a few questions
Download Resource
A novel mouse model using optical imaging to detect on-target, off-tumor CAR-T cell toxicity