M-PVA C11 magnetic beads: a tool towards analysis of RNA-binding proteins

Advancing RNA-interactome capture with M-PVA C11 Magnetic Beads

RNA-binding proteins (RBPs) govern gene expression, stress response, and disease — yet capturing them with precision has remained a challenge. Discover how M-PVA C11 Magnetic Beads are enabling a new standard in RBP analysis.

The challenge of RNA interactome capture routines

Standard RNA Interactome Capture (RIC) methods suffer from contamination by RNA, DNA, and DNA-binding proteins — reducing sensitivity and leaving critical biology undetected. RBPs are more numerous and dynamic than once thought. As the field advances, so must the tools. Researchers need a capture platform that delivers higher specificity, lower background, and flexible functionalization.

eRIC with M-PVA C11 Magnetic Beads

Enhanced RNA Interactome Capture (eRIC) builds on the proven RIC workflow — replacing standard pre-coated beads with carboxylated M-PVA C11 Magnetic Beads functionalized with LNA-modified oligo(dT) probes. As result, there is a 10-fold increase in method specificity — enabling detection of subtle, dynamic RNA-interactome changes that were previously impossible to observe.

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For research use only. Not for use in diagnostic procedures.