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pbr assay applications characterization of anti obesity molecules glp1 hero

Literature - Publication Review

Homogenous fluorescent assay applications for the characterization of anti-obesity molecules.

In this literature review, we examine how TR-FRET and Alpha technologies are being used to profile promising molecules targeting key GPCRs such as GLP-1R, GIPR, MC4R, and more. Drawing from recent studies on Tirzepatide, GL0034, and nanobody agonists, the review showcases:

Functional assay formats for cAMP and IP1 accumulation
Real-time receptor internalization and binding assays
Downstream insulin secretion measurements in pancreatic islets
Biased agonism and secondary G protein coupling insights

For research use only. Not for use in diagnostic procedures.

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Homogenous fluorescent assay applications for the characterization of anti-obesity molecules.

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