This application note describes an optimized dual-guide CRISPR knockout screening platform, its applications, and the advantages it offers over conventional single-guide screening methods.
It also demonstrates Revvity's preclinical services capabilities to perform dual CRISPRko screens to examine gene interactions and synthetic lethality. Our team can manage the whole process, from custom library design to sophisticated data analysis, so that you can focus on the biological insights rather than the technical challenges of implementing dual guide screens.
Dual-guide CRISPR Cas9-knockout screening for gene‑gene interaction analysis and beyond.