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Application Note
CRISPRi: Transcriptional repression screening with genome-wide CRISPR interference
In this application note, we present a novel all-in-one human whole-genome CRISPRi platform. We demonstrate its effectiveness in identifying resistance and sensitivity genes to the BRAF inhibitor vemurafenib.
The ability to negatively control transcription by several orders of magnitude offers researchers the opportunity to identify novel hits in both positive and negative selection screens where dCas9 is non-mutagenic.
For research use only. Not for use in diagnostic procedures.
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CRISPRi: Transcriptional repression screening with genome-wide CRISPR interference