AI-Enhanced ABE Development with the Pin-point™ Platform

Revvity and Profluent collaborated to create five AI-engineered adenine deaminases optimized for the modular Pin-point™ base editing system. This poster showcases their editing performance across genomic contexts and cell models.

What’s Inside the Poster

• Five AI-designed ABEs: Strong A→G editing with distinct precision profiles.
• Plug-and-play modularity: Swap Cas, deaminase, and sgRNA components with ease.
• High performance in primary cells: Efficient editing in iPSCs and HSPCs.
• Aptamer-dependent activity: Editing occurs only with the engineered sgRNA scaffold.
• Tunable precision: Adjust deaminase dose to reduce bystander editing.

Why It Matters

Combining AI-designed enzymes with modular architecture enables highly customizable, high-precision adenine base editing.

Pin-point™ Reagents & Platform: Pin-point™ base editing reagents are available for research use only and are not for diagnostic use or direct administration into humans or animals. The Pin-point™ base editing platform technology is available for clinical or diagnostic study and commercialization under a commercial license from Revvity.