Microphysiological systems, such as spheroids, organoids, and organ-on-chips, are revolutionizing cancer research by providing physiologically relevant 3D models that offer the potential for more predictive and personalized drug screening than traditional 2D cell cultures.

Despite their promise, scaling 3D cell models for high-throughput drug discovery remains challenging due to complex handling requirements, sample heterogeneity, and sophisticated imaging demands.

In this literature review, you’ll discover how researchers have successfully implemented automated high-content screening assays using different 3D cancer models for high-throughput drug discovery:

• Metastasis-on-chip platform for anti-cancer drug screening
• Automated organoid workflows enabling high-content, multi-modal analysis of drug responses
• Scalable spheroid systems for subcellular drug mechanism studies

For research use only. Not for use in diagnostic procedures.