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RNA Interference

Dharmacon™ siRNA, shRNA and microRNA solutions

RNA interference (RNAi) remains the most simplest yet effective method for target gene knockdown in loss-of-function experiments. Revvity’s Dharmacon reagents have pioneered the development of novel siRNA, shRNA, and microRNA technology for nearly 30 years, offering a broad portfolio of trusted synthetic and expressed reagents for highly specific and efficient gene silencing.

For research use only. Not for use in diagnostic procedures. 

rna interference

siRNA

High quality siRNA design and synthesis.

Featured products:

  • ON-TARGETplus™ siRNA
  • Accell™ siRNA
  • siGENOME™ siRNA

Featured resources:

  • RNAi applications

shRNA

Dharmacon lentiviral shRNA reagents for long-term, inducible, and in vivo targeted gene silencing.

Our premium shRNA products use a microRNA-adapted shRNA design to promote more efficient cellular processing and reduce toxicity during RNAi experiments.

Featured products:

  • SMARTvector™ lentiviral shRNA 
    *Conditions apply  
  • SMARTvector inducible lentiviral shRNA
  • GIPZ lentiviral shRNA
  • TRIPZ inducible lentiviral shRNA
  • TRC lentiviral shRNA

Featured resources:

  • shRNA applications 

microRNA

Dharmacon miRNA modulation reagents - trusted for interrogating microRNA function.

Modulation of miRNA levels is a fundamental way to understand not only microRNA function, but also the pathways in which they are involved. Revvity offers reliable miRNA mimic and inhibitor reagents for every mature human, mouse and rat miRNA in the miRBase database 21.0.

Featured products:

  • miRIDIAN™ microRNA mimics
  • shMIMIC lentiviral microRNA
  • shMIMIC inducible lentiviral microRNA
  • miRIDIAN microRNA hairpin inhibitors
  • Custom microRNA design

Featured resources:

  • miRNA applications 

Long non-coding RNA

Dharmacon Lincode™ siRNA Reagents

Knockdown of long noncoding RNA (lncRNA)

Expert siRNA design and specificity-enhancing modifications for effective knockdown of human long non-coding RNA. Pre-designed Lincode siRNA is available as individual reagents and SMARTpool™ format.

Learn more

RNAi libraries

Flexible, convenient and high-confidence screening results. Choose from Revvity’s Dharmacon siRNA, shRNA and microRNA pre-designed libraries. Small gene families to genome-wide collections.

Featured products

siRNA screening libraries: 

  • siRNA Screening Libraries
  • Human siRNA libraries
  • Mouse siRNA libraries 

shRNA screening libraries:

  • Cherry-pick clone libraries
  • SMARTvector lentiviral shRNA pooled libraries
  • GIPZ lentiviral shRNA libraries
  • TRIPZ inducible lentiviral shRNA libraries
  • TRC lentiviral shRNA libraries
  • Pooled lentiviral screening libraries
  • SMARTvector inducible lentiviral shRNA pooled libraries

microRNA screening libraries:

  • Cherry-pick libraries
  • miRIDIAN microRNA libraries
  • Pooled lentiviral screening libraries

Custom screening libraries:

  • Synthetic cherry-pick libraries
  • Lentiviral cherry-pick clone libraries

Featured resources

Article

Top tips for effective gene silencing in 3D cultures

Learn more

Questions?
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